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Medical applications of phytoestrogens from the …

 

Medical applications of phytoestrogens from the …

ISSN 2095-0217 ISSN 2095-0225(Online) CN 11-5983/R 2015 Impact Factor: 1.863Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.London: Taylor & Francis, 2002: 97-118 2 Bodner CC, Hymowitz T. Ethnobotany of Pueraria species. In: Keung WM, ed. Pueraria: The genus Pueraria . London: Taylor & Francis, 2002: 29-58 3 Cherdshewasart W, Kitsamai Y, Malaivijitnond S. Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay. J Reprod Dev 2007; 53(2): 385-393 doi: 10.1262/jrd.18065 pmid:17229996 4 Van der Maesen LJG. Pueraria: botanical characteristics. In: Keung WM, ed. Pueraria: The genus Pueraria . London: Taylor &Francis, 2002: 1-28 5 Malaivijitnond S, Chansri K, Kijkuokul P, Urasopon N, Cherdshewasart W. 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